When 34-year-old twins Mary and Ruth appeared on The Oprah Show in 2005, Mary was 300 pounds heavier than her sister. While Mary said she always felt like “the fat twin,” Ruth obsessed over her own weight and battled eating disorders. During the show, Ruth admitted to being embarrassed by her sister’s overeating, and Mary’s son shared his concerns about his mother’s weight. Then, six years later, a devastating tragedy ultimately pushed Mary to take control of her health. Watch her emotional update.